Radiation Technology for the Manufacture of Medical Products with Nanosilver: from Development to Commercialization





innovation, medical, technology, development, roadmap of commercialization


Introduction. The distance between the obtainment of a researchresult and the appearance on the market of a new product is large in the sense of time and efforts and has certain specific features, depending on industry.
Problem Statement. The search and implementation of advanced materials,in particular in the field of radiation technology for the manufacture of medical products from metal-water-polymer nanocomposite is an urgent task today.
Purpose. The purpose of this research is the popularization of the technology for the manufacture of medical products from metal-water-polymer nanocomposite and the dissemination of experience in bringing R&D product to commercialization.
Material and Methods. High molecular weight polymers, silver salts, and water have been used. The electron irradiation method, optical spectroscopy, electron microscopy, microbiological analysis, and the method for curing thermal injuries and purulent wounds.
Results. The regularities of the effect of radiation on the microstructure and properties of hydrogels based on the polyvinyl alcohol — polyethylene glycol system and on the formation and stability of silver nanoparticles in the composition of 3D polymer networkshave been established. A technology for manufacturing a metal-waterpolymer nanocomposite with nanosilver has been developed; the bactericidal properties of the nanocomposite have been experimentally demonstrated. The technology formanufacturingmedical products from this nanocomposite under the HYDROBINT trademark has been developed and put into production. The organizational and technical procedures for the state certification of HYDROBINT medical products, asestablished by the legislation of Ukraine, have been described. The medical results of their use have been illustrated. A road map of developer’sactions for commercialization of innovation product has been proposed.
Conclusions. Electronic irradiation of polymer hydrogels makes it possible to create new composite materials with properties relevant for the treatment of wounds and inflammations. The products made of such composites are effective in medical practice and commercially attractive in the market. Practical recommendations for the commercialization of an R & D innovation in the form of a roadmap for the developer’s actions have been offered.


Download data is not yet available.


Vaznychya, O. M., Bobrova, N. O., Gancho, O. V., Loban, G. A. (2014). Silver nanoparticles: antibacterial and antifungal properties. Pharmacology and medicinal toxicology, 38(2), 3-11 [in Ukrainian]. URL: http://nbuv.gov.ua/UJRN/flt_ 2014_2_2 (Last accessed: 28.03.2022).

Chekman, I. S., Movchan, B. A., Zagorodniy, M. I. (2008).Nanosilver: production technologies, pharmacological properties, indications for use. Preparations and technologies, 3, 32-34 [in Russian].

Bera, A. P., Garai, R., Singh, P. P., Gupta, Sh., Malav, D., Singh, D., Kumar, B. L., Tiwari, S., Vaijapurkar, G. (2015). Ga mma radiation synthesis of colloidal AgNPs for its potential application in


Stanishevskaya, I. E., Stoinova, A. M., Marakhova, A. I., Stanishevskiy, Y. M. (2016). Silver nanoparticles: preparation and use for medical purposes. Drug development & registration, 1, 66-69.

Selim, H. M., Mohamed, D. S., Eskander, H. M. G. (2017). Silver Nanoparticles: Synthesis, Medical Application, and Toxicity Effects. Int. J. Nanotech. Allied. Sci., 1(1), 45-53.

Mahendra Rai, Alka Yadav, Aniket Gade. (2009). Silver nanoparticles as a new generation of antimicrobials. Biotechnology Advances, 27(1), 76-83. https://doi.org/10.1016/j.biotechadv.2008.09.002

Nelson Durán, Marcela Durán, Marcelo Bispo de Jesus, Amedea B. Seabra, Wagner J. Fávaro, Gerson Nakazato. (2016). Silver nanoparticles: A new view on mechanistic aspects on antimicrobial activity. Nanomedicine: Nanotechnology, Biology and Medicine, 12(3), 789-799.


Xiu, Z. M., Zhang, Q. B., Puppala, H. L., Colvin, V. L., Alvarez, P. J. (2012). Negligible particle-specific antibacterial activity of silver nanoparticles. Nano Lett., 12(8), 4271-4275.


Technical regulation on medical devices, approved by the resolution of the Cabinet of Ministers of Ukraine. October 2, 2013 No. 753. [in Ukrainian]. URL: https://zakon.rada.gov.ua/laws/show/753-2013-%D0%BF#Text(Last accessed: 22.03.2022).

Neimash, V. B., Kupianskyii, H. D.,Olkhovyk, I. V., …,Titarenko, S. M. (2019). Formation of Silver Nanoparticles in PVA-PEG Hydrogel under Electron Irradiation. Ukrainian Journal of Physics, 64(1), 41-46. URL: http://nbuv.gov.ua/ UJRN/UPhJ_2019_64_1_8 (Last accessed: 22.03.2022).


Rupali S. Patil, Mangesh R. Kokate, Chitra L. Jambhale, Sambhaji M. Pawar, Sung H. Han, Sanjay S. Kolekar. (2012). One-pot synthesis of PVA-capped silver nanoparticles their characterization and biomedical application. Adv. Nat. Sci: Nanosci. Nanotechnol., 3(1), 015013.


Skiba, M., Pivovarov, A., Makarova, A., Vorobyova, V. (2017). Method for Obtaining Nanodispersion of Silver under the Influence of Plasma Discharge in the Presence of Water-Soluble Polymers. Research Bulletin of the National Technical University of Ukraine "Kyiv Politechnic Institute", 6, 112-119. https://doi.org/10.20535/1810-0546.2017.6.103890

Tamayo, L., Palza, H., Bejarano, J., Zapata, P. (2019). Polymer Composites With Metal Nanoparticles: Synthesis, Properties and Applications. In Micro and Nano Technologies, Polymer Composites with Functionalized Nanoparticles, 249-286. https://doi.org/10.1016/B978-0-12-814064-2.00008-1

Patent of Ukraine for the invention No. 113797 (UA113797 C2). The method of manufacturing hydrogel bandages for wounds. Neimash V. B., Kabaldin O. M. [in Ukrainian].

Neimash, V. B., Kupyanskyi, G. D., Olkhovyk, I. V., Povarchuk, V. Yu., Rogutskyi, I. S. (2017). Physical properties of polyvinyl alcohol-polyethylene glycol hydrogels in the context of application in medical bandages. Ukraine physics journal, 62(5), 400-409.


Nadtoka, O., Kutsevol, N., Onanko, A., Neimash, V. (2017). Mechanical and Thermal Characteristics of Irradiation Cross-linked Hydrogels. Chapter 12. (Еds. Fesenko O., Yatsenko L.) Nanochemistry, Biotechnology, Nanomaterials, and Their Applications. NANO 2017. Springer Proceedings in Physics, 214, 205-214.


Patent of Ukraine for the invention UA120991. The method of manufacturing medical bactericidal dressings with silver nanoparticles. Neimash V. B., Kupyanskyi G. D., Olkhovyk I. V., Povarchuk V. Yu., Rogutskyi I.S.

Caló, E., Khutoryanskiy, V. (2015). Biomedical applications of hydrogels: A review of patents and commercial products. European Polymer Journal, 65, 252-267.


Abd El-Mohdy, H. L. (2013). Radiation synthesis of nanosilver/poly vinyl alcohol/cellulose acetate/gelatin hydrogels for wound dressing. J. Polym. Res., 20, 177. https://doi.org/10.1007/s10965-013-0177-6

Meikle, S. (2016). Silver-doped hydrogels for wound dressings. In book: Wound Healing Biomaterials. 335-351. https://doi.org/10.1016/B978-1-78242-456-7.00016-7

Oliveira, R. N., Rouzé, R., Quilty, B., Alves, G. G., Soares, G. D., Thiré, R. M., Mc Guinness, G. B. (2014). Mechanical pro perties and in vitro characterization of polyvinyl alcohol-nano-silver hydrogel wound dressings. Interface Focus, 4(1), 20130049. https://doi.org/10.1098/rsfs.2013.0049

DSTU EN ISO 11137-2:2018 Sterilization of medical devices. Radiation sterilization. Part 2. Setting the sterilizing dose [in Ukrainian].

Sukdeb Pal, Yu Kyung Tak, JoonMyong Song. (2007). Does the Antibacterial Activity of Silver Nanoparticles Depend on the Shape of the Nanoparticle? A Study of the Gram-Negative Bacterium Escherichia coli. Applied and Environmental Microbiology, 73(6), 1712-1720. https://doi.org/10.1128/AEM.02218-06

Bilankohi, S. M. (2015). Optical Scattering and Absorption Characteristics of Silver and Silica/Silver Core/shell Nanoparticles. Orient J. Chem., 31(4), 2259-2263. https://doi.org/10.13005/ojc/310452

Malynych, S. (2010). Estimation of Size and Concentration of Silver Nanoparticles in Aqueous Suspensions from Extinction Spectra. Journal of Nano- and Electronic Physics, 78(4), 5-11.

Saion, E., Gharibshahi, E, Naghavi, K. (2013). Size-controlled and optical properties of monodispersed silver nanoparticles synthesized by the radiolytic reduction method. Int. J. Mol. Sci., 14(4), 7880-7896. https://doi.org/10.3390/ijms

Agnihotri, S., Mukherji, S., Mukherji, S. (2014). Size-Controlled Silver Nanoparticles Synthesized over the Range 5-100 nm Using the Same Protocol and Their Antibacterial Efficacy. RSC Advances, 4, 3974-3983. https://doi.org/10.1039/C3RA44507K

State enterprise "Ukrainian Institute of Intellectual Property" (Ukrpatent). URL: https://www.ukrpatent.org/ (Last accessed: 18.07.2022).

RADITECH (radiation technologies). URL: http://www.radi-tech.org.ua/index.php?option=com_content&view=arti cle&id=73&Itemid=56 (Last accessed: 18.07.2022)




How to Cite

Neimash В. (2022). Radiation Technology for the Manufacture of Medical Products with Nanosilver: from Development to Commercialization. Science and Innovation, 18(5), 69–84. https://doi.org/10.15407/scine18.05.069



Scientific and Technical Innovation Projects of the National Academy of Sciences