Innovation Technologies for Human Microbiome Improvement

1Yankovsky, DS
2Shirobokov, VP
1Dyment, GS
1OD Prolisok Research & Production Company
2O.O. Bogomolets National Medical University
Sci. innov. 2018, 14(6):11-21
https://doi.org/10.15407/scine14.06.011
Section: Scientific Basis of Innovation Activity
Language: English
Abstract: 

Introduction. In recent years, the human microbiome studies have been a relevant direction of biomedical sciences. A progress in the modern science has enabled to consider the microbiome as an additional human organ. It is involved in digestion and many other metabolic processes, as well as in maintaining the integrity of epithelial barrier, organizing the colonization resistance, neutralizing endo- and exogenous toxins, developing and maintaining the immune system and other physiologic functions; also, it optimizes conditions for normal functioning of the human organism as a whole. Therefore, maintaining the physiologic state of microbiome at all stages of the human life, from the early life till the extreme old age, has an enormous importance for promoting good health of population at any age.
Problems. There has been observed an increase in the number of children and adults suffering from diseases associated with microbiome dysfunctions. Therefore, developing innovative means for microbiome improvement and creation of new methodologies for their clinical application is an important contribution to maintenance of the public health, treatment and prevention of many diseases.
Purpose. Developing innovative technologies for human microbiome improvement.
Materials and Methods. Methods for theoretical generalization, microbiological, biochemical and genetic research methods.
Results. Modern research in the field of human microbial ecology has been generalized. New generation technologies for producing means of microbiome improvement have been developed. Treatment regimens have been created for patients with different profiles.
Conclusion. Innovative biological technologies that provide means of microbiome improvement with high multifunctional biotherapeutic efficiency have been created. In particular, new generation multiprobiotics, unique enterosorbent prebiotics, and complex means of probiotic and sorption therapy have been designed. The results ensure effective means that facilitate the formation, maintenance, and restoration of healthy microbiome at all stages of human ontogenesis, from the birth to the extreme old age.

Keywords: enterosorbents, microbiome, microbiota, probiotics, symbiosis, «Symbiogel», «Symbiter»
References: 
1. Shyrobokov, V. P., Yankovskyy, D. S., Dyment, G. S. (2011). Microbna ecologia ludyny z kolorovym atlasom (navchalnyi posibnyk). Кyiv: Chervona Ruta-Turs [in Ukrainian].
2. Shyrobokov, V. P., Yankovskyy, D. S., Dyment, G. S. (2011, September). Bioeticheskie problemy ispolsovania probiotikov v medicine. IV Nacionalnyi kongress po bioetike, Кiev [in Russian].
3. Shyrobokov, V. P., Yankovskyy, D. S., Dyment, G. S. (2011, May). Мicrobnaia ekologicheskaia sistema cheloveka: sovremennaia koncepcia. Naukovo-praktychna konferensia «Мikrobna екologia liudyny. Suchasni strategii vykorystannia probiotykiv», Kiev [in Russian].
4. Yankovskyy, D. S., Shyrobokov, V. P., Dyment, G. S. (2018). Microbiom. Kiev: FOP Veres O.I. [in Russian].
5. Lederberg, J., McCray, A. T. (2001). ‘Ome sweet ‘omics - A genealogical treasury of words.   Scientist, 15(7), 8. 
6. Yankovskyy, D. S., Shyrobokov, V. P., Dyment, G. S. (2011). Integralnaia rol simbioticheskoi mikroflory v fiziologii cheloveka. Kiev: Chervona Ruta-Turs  [in Russian].
7. Yankovskyy, D. S., Shyrobokov, V. P., Volosovec, A. P., Moiseenko, R. A., Dyment, G. S. (2013). Microbiom cheloveka i sovremennye metody eho ozdorovlenia. Jurnal nacionalnoi akademii nauk Ukrainy, 4, 411-420 [in Russian].
8. Shreiner, A. B., Kao, J. Y., Young, V. B. (2015). The gut microbiome in health and in disease. Curr. Opin. Gastroenterol., 31, 69-75.
https://doi.org/10.1097/MOG.0000000000000139
9. Nicholson, J. K., Holmes, E., Kinross, J., Burcelin, R., Gibson, G., Jia, W., Pettersson, S. (2012). Host-gut microbiota metabolic interactions. Science, 336, 1262-1267.
https://doi.org/10.1126/science.1223813
10. Yankovskyy, D. S., Dyment, G. S. (2007). Probioticheskaia optimizacia pervichnoho formirovania normalnykh biocenozov v neonatalnom vozraste - zalog preduprejdjenia disbiozov. Reproductivnoe zdorovie jenshchiny, 3, 192-199 [in Russian].
11. Yankovskyy, D. S., Antipkin, J. G., Dyment, G. S., Znamenskaia, T. K., Shunko, E. E., Davydova, J. V. (2015). Mikrobnaia ekologia novorojdennykh: osobennosti formirovania microbioma i profilaktika eho narushenii. Neonatologia, hirurgia ta perynatalna medycyna, 5(2), 93-105 [in Russian].
https://doi.org/10.24061/2413-4260.V.2.16.2015.18
12. Yankovskyy, D. S., Dyment, G. S. (2005). Era probiotikov. Protivorechia, problemy, diskussii. Kolega, 3–4 [in Russian].
13. Yankovskyy, D. S., Dyment, G. S. (2005). Sovremennye aspekty problemy mikroekologii i disbiozov. Zdorovie jenshchiny, 4(24), 209–218 [in Russian].
14. Yankovskyy, D. S., Dyment, G. S. (2006). Problema rezistentnosti mikroflory k antibiotikam i rol sovremennykh probiotikov v eho realizacii. Zdorovie jenshchiny, 2(26), 1–9 [in Russian].
15. Yankovskyy, D. S., Dyment, G. S. (2006, June). Probiotiki ХХI stoletiia. Dostijeniia, problemy, diskussii. Naukovo-praktychna konferensia «Rol probiotykiv v okhoroni zdorovia materi ta dytyny», Kyiv [in Russian].
16. Shyrobokov, V. P., Yankovskyy, D. S., Dyment, G. S. (2014). Microby v biogeokhimicheskikh processakh, evolucii biosfery i sushchestvovanii chelovechestva. Кiev: FOP Veres O.I.  [in Russian].
17. Arrieta, M. C., Stiemsma, L. T., Amenyogbe, N., Brown, E. M., Finlay, B. (2014). The intestinal microbiome in early life: Health and disease. Front. Immunol., 5, 427. eCollection 2014.
https://doi.org/10.3389/fimmu.2014.00427
18. Zhou, L., Foster, J. A. (2015). Psychobiotics and the gut-brain axis: in the pursuit of happiness. Neuropsychiatr. Dis Treat., 11, 715-723.
https://doi.org/10.2147/NDT.S61997
19. Yankovskyy, D. S., Dyment, G. S. (2007). Sovremennoe sostoianie problemy poluchenia i klinicheskoho primenenia probiotikov. Sovremennaia pediatria, 2(15), 136–146 [in Russian].
20. Yankovskyy, D. S., Dyment, G. S. (2007). Biologicheskaia harakteristika i perspektivy ispolzovania otdeljnykh vidov microorganizmov v sostave probiotikov. Zdorovie jenshchiny, 2(30), 221–234 [in Russian].
21. Shyrobokov, V. P., Yankovskyy, D. S., Dyment, G. S. (2008). Perspektivy ispoljzovania bentonita pri sozdanii novoho vida multiprobiotikov. Sovremennaia pediatria, 4(21), 143-154 [in Russian].
22. Shyrobokov, V. P., Yankovskyy, D. S., Dyment, G. S. (2010). Novye strategii v oblasti sozdania i klinicheskoho ispolzovania probiotikov. Visnyk farmakologii ta farmacii, 2, 18-30 [in Russian].
23. Shyrobokov, V. P., Yankovskyy, D. S., Dyment, G. S. (2015). Sozdanie ozdorovitelnykh sredstv novoho pokolenia na osnove smektita. Vrachebnoe delo, 1/2, 3-9 [in Russian].
24. Yankovskyy, D. S., Dyment, G. S. (2008). Mikroflora i zdorovie cheloveka, Кiev: Chervona Ruta-Turs [in Russian].
25. Yankovskyy, D. S., Moiseenko, R. A., Dyment, G. S. (2010). Mesto disbioza v patologii cheloveka. Sovremennaia pediatria, 1(29), 154-167 [in Russian].
26. Yankovskyy, D. S., Shyrobokov, V. P., Moiseenko, R. A., Volosovec, A. P., Krivopustov, S. P., Dyment, G. S. (2010). Disbiozy i sovremennye podkhody k ikh profilaktike. Sovremennaia pediatria, 3(31), 143-151 [in Russian].
27. Yankovskyy, D. S., Shyrobokov, V. P., Moiseenko, R. A., Volosovec, A. P., Krivopustov, S. P., Dyment, G. S. (2010). Sovremennye vozmojnosti profilactiki disbiozov u detei i vzroslykh. Profilaktychna medycyna, 4, 69-76 [in Russian].
28. Yankovskyy, D. S., Shyrobokov, V. P., Moiseenko, R. A., Krivopustov, S. P., Dyment, G. S. (2013). Novoe pokolenie enterosorbentov i kompleksnykh probiotikov dla ozdorovlenia mikrobnoi ekologii cheloveka. Sovremennaia pediatria,  6(54), 1-9 [in Russian].
29. Yankovskyy, D. S., Shyrobokov, V. P., Dyment, G. S., Moiseenko, R. A., Martyniuk, V. J., Shunko, E. E., Berejnoi, V. V. (2014). Microekologicheskie aspekty zabolevanii centralnoi nervnoi sistemy u detei. Socialna pediatria ta reabitalogia, 1(7), 70-76 [in Russian].
30. Yankovskyy, D. S., Shyrobokov, V. P., Antipkin, J. G., Tatarchuk, T. F., Dyment, G. S. (2015). Mikrobiom i zdorovie jenshchiny. Reproduktivnaia endokrinologia, 4(24), 40-55 [in Russian].
31. Shyrobokov, V. P., Yankovskyy, D. S., Dyment, G. S. (2012). Svit glyn i zdorovia ludyny. Svitogliad, 2(34), 6-17 [in Ukrainian].
32. Kramarev, S. A., Yankovskyy, D. S., Dyment, G. S. (2007). Povyshenie effektivnosti terapii invazivnykh ostrykh kishechnykh infekcii u detei. Sovremennaia pediatria, 1, 172–174 [in Russian].
33. Lukianova, O. M., Denysova, M. F., Muzyka, N. M. (2006, June). Stan mikrobiocenozu kyshechnyka u ditei z hronichnymy gepatytamy. Naukovo-praktychna konferensia «Rol probiotykiv v okhoroni zdorovia materi ta dytyny», Kyiv [in Ukrainian].
34. Gorpinchenko, I. I., Melnikov, S. N., Kornienko, A. M., Dobrovolskaia, L. I. (2006).  Ispolzovanie multiprobiotika Apibakt v kompleksnom lechenii urogenitaljnykh infekcionnykh zabolevanii u suprujeskoi pary. Zdorovie mujchiny, 3, 72–76 [in Russian].
35. Mukvich, O. M. (2007). Efektyvnist protyrecydyvnykh kursiv multiprobiotyka Apibakt u ditei z zahvoruvanniamy organiv travlennia. Sovremennaia pediatria, 4(17), 162–166 [in Ukrainian].